A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/153
A61K 47/00 (2006.01) A61K 9/00 (2006.01)
Patent
CA 1083041
SUSTAINED RELEASE DRUG DELIVERY DEVICE AND PROCESS FOR MAKING SAME ABSTRACT OF THE DISCLOSURE Sustained release diffusional drug delivery devices for use in an aqueous body environment are disclosed. The devices are in the form of an integral solid body that is sized and shaped for placement and retention in the environment and are made from a mixture of drug, polymer, and a small amount of discrete depots of an osmotically effective solute. The polymer is permeable to water and drug, insoluble in the environment, and impermeable to the solute. The solute depots are dispersed in the polymer such that they are encapsulated sub- stantially individually by a layer of polymer. When the device is placed in the environment, the depots imbibe water and burst the polymer layers surrounding them, thereby forming a network of interconnected pores through the device and thus increasing in situ the surface area from which drug may be released from the polymer to the environment. This in situ increase in surface area increases the rate of drug release from the device.
257322
Alza Corporation
Smart & Biggar
LandOfFree
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