Stabilization of hydrolysis prone labile organic reagents in...

Details Stabilization of hydrolysis prone labile organic reagents in... Stabilization of hydrolysis prone labile organic reagents in...

A - Human Necessities

61

K

150/9

A61K 49/00 (2006.01) G01N 33/50 (2006.01) G01N 33/96 (2006.01) G01N 33/72 (2006.01) G01N 33/82 (2006.01) G01N 33/84 (2006.01) G01N 33/92 (2006.01)

Patent

CA 1132034

ABSTRACT A labile, organic reagent which is unstable in aqueous media and stable in a non-aqueous media is stabilized by dissolving the organic reagent in a water-miscible, organic solvent which is liquid at room temperature and which is nondegradatively reactive with the organic reagent to form a solution of the organic reagent in the organic solvent. At least 1% of an inert, high surface area particulate dessicant is added to the solution for entrapping water with the dessicant so that the residual water content of the solution is below about 0.5%. The dessicant can be removed from the solution before sealing it. More than one organic reagent can be added to the solvent, and a solubilizing agent for the organic reagent can be used.

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