Process for the preparation of penicillin derivatives

Details Process for the preparation of penicillin derivatives Process for the preparation of penicillin derivatives

C - Chemistry, Metallurgy

12

P

195/98

C12P 37/00 (2006.01) C07D 499/00 (2006.01) C12N 9/18 (2006.01)

Patent

CA 1153327

ABSTRACT A process for the preparation of .alpha.-carboxy, 6, .alpha.- methoxy penicillin derivatives by the enzymatic hydro- lysis of an esterified derivative. The process is for the preparation of a compound of formula (I): Image (I) wherein R represents phenyl or 2- or 3-thienyl, which process comprises subjecting a compound of formula (IV): Image (IV) where R1 is an aryl radical, to the action of an enzyme selected from bromelain, papain, gelatase, trypsin, pancreatin or an esterase-producing strain of Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger or Saccharomyces sp.

351903

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