Method of producing a factor-viii(ahf)-high- concentrate

Details Method of producing a factor-viii(ahf)-high- concentrate Method of producing a factor-viii(ahf)-high- concentrate

A - Human Necessities

61

K

167/103.34

A61K 35/16 (2006.01) C07K 14/755 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1160567

ABSTRACT OF THE DISCLOSURE: In a method of producing a factor-VIII(AHF)-high-concentrate having a specific activity of at least 2.5 units AHF and a fibrinogen content of less than 0.25 mg/mg protein from human or animal plasma, the plasma is subjected to a multi- step fractionation. The fraction purified by these fractio- nation measures and enriched in factor VIII (AHF) is sub- jected to a cryoalcohol precipitation and the resulting precipitate is processed into a stable form.

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