Compositions containing synthetic conjugated estrogens and...

Details Compositions containing synthetic conjugated estrogens and... Compositions containing synthetic conjugated estrogens and...

A - Human Necessities

61

K

167/192

A61K 31/56 (2006.01)

Patent

CA 1100407

ABSTRACT OF THE DISCLOSURE A new and remarkably stable synthesized conjugated estrogen composition comprising one or more selected alkali metal synthetic conjugated estrogen sulfate salts and an effective amount of one or more suitable antioxidants has been found for use in novel and stable therapeutic preparations of a pH of not less than about 7 which are adapted to relieve, inter alia, complaints occurring in the menopausal syndrome and other female complaints. Preferably, the steroids are selected from the sodium and potassium salts of the group consisting of estrone, equilin, 17.alpha.-dihydroequilin, and mix- tures or conjugates thereof. Most preferably, the prepara- tions are so formulated so that sodium estrone sulfate, sodium equilin sulphate, and 17.alpha.-dihydroequilin sodium sulphate as conjugated estrogens are present in a weight ratio of about 6:3:1, respectively and administered in tablets containing 0.625 mg, 1.25 mg, or 2.5 mg of total conjugated estrogens.

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