Amino-substituted 4,5,6,7-tetrahydro-1h (or 2h)-indazoles

C - Chemistry – Metallurgy – 07 – D

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260/315.35

C07D 231/56 (2006.01)

Patent

CA 1120932

- 1 - Abstract of the Disclosure Described herein are novel amino-substituted- 4,5,6,7-tetrahydro-1H (or 2H)-indazoles of the formulae Image Image I II wherein one of R and R1 is H and the other is N(R2)2; where each R2 is individually allyl, methyl, ethyl or n-propyl; .and pharmaceutically-acceptable acid addition salts thereof. These compounds are useful as prolactin inhibitors and in the treatment of Parkinson's Syndrome. They are prepared by reacting, by reductive alkylation with an aldehyde or by reacting with an alkyl halide or anhydride followed by reduction, an 5 (or 6)-amino-4,5,6,7-tetrahydro- 1H (or 2H)-indazole compound of the formulae Image Image IB IIB wherein one of R and R1 is H and the other is N(R2)2 wh.ere both R2's are H.

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