Process for the preparation of new pyridine derivatives

Details Process for the preparation of new pyridine derivatives Process for the preparation of new pyridine derivatives

C - Chemistry, Metallurgy

07

D

150/19

C07D 495/04 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1038871

ABSTRACT OF THE DISCLOSURE This invention relates to a process for the preparation of new pyridine derivatives having the formula: Image in which X represents oxygen or sulfur; R represents a phenyl which may be substituted by halogen, alkyl containing 1 to 6 carbon atoms, alkoxy con- taining 1 to 6 carbon atoms, nitro, or hydroxy; or benzoyl which may be sub- stituted by halogen, alkyl containing 1 to 6 carbon atoms, alkoxy containing 1 to 6 carbon atoms, nitro, or hydroxy; R1 represents hydrogen, hydroxy, or alkyl containing 1 to 6 carbon atoms; R2 represents hydrogen or halogen and n is one or two; and in which the symbols R1 may have different meanings in each radical -(CHR1)- when n is two; their pharmaceutically acceptable acid addition and quaternary ammonium salts. Said derivatives are therapeutic- ally useful for their anti-inflammatory action, their vaso-dilatator action and for their inhibitor action on blood plaque aggregation.

191469

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