Substituted azol-1-ylmethanes

Details Substituted azol-1-ylmethanes Substituted azol-1-ylmethanes

C - Chemistry, Metallurgy

07

D

260/313, 260/315

C07D 231/12 (2006.01) C07C 29/143 (2006.01) C07D 233/54 (2006.01) C07D 249/08 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1059134

Abstract Azol-1-ylmethanes of the formula Image in which R1 is hydrogen, halo, haloalkyl, alkyl, alkoxy, nitro or cyano, R2 is alkyl or optionally substituted aryl, X is a single carbon-carbon bond, oxygen, sulphur, thionyl or sulphonyl, Az is imidazol-1-yl, pyrazol-1-yl, 1,2,4- triazol-1-yl or 1,2,4-triazol-4-yl, and n is an integer of from 1 to 4 and salts thereof, are prepared from the correspondingly substituted carbinol through treatment with thinyl-bis-azole or from the correspondingly substituted methyl halide with the azole or a derivative thereof. The compounds, of which (biphenyl-4-yl)phenyl-imidazol-1-ylmethane is a typical example, are antimycotic and antibacterial agents.

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