Process for the production of novel antibacterial amide...

Details Process for the production of novel antibacterial amide... Process for the production of novel antibacterial amide...

C - Chemistry, Metallurgy

07

D

260/102, 260/104

C07D 499/70 (2006.01) C07D 211/22 (2006.01) C07D 213/78 (2006.01) C07D 213/80 (2006.01) C07D 213/82 (2006.01) C07D 213/85 (2006.01) C07D 499/00 (2006.01) C07D 501/20 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1097614

Abstract of the Disclosure Novel organic amide compounds which are N-[6- [(aminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinyl]penicillin and cephalosporin type compounds having broad spectrum anti- bacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or cephalosporin or the acid salt or silylated derivative or complex thereof with reactive derivative of the corresponding N-6-[(aminosulfonyl)phenyl]-1,2- dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid, 7-aminocephalosporanic acid, 7-amino- 3-methylceph-3-em-4-carboxylic acid or a related compound or the acid salt or silylated derivative thereof with a reactive deri- vative of the corresponding D-N-[6-[(aminosulfonyl)phenyl]-1,2- dihydroxo-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed. -1-

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