Slow release bolus

Details Slow release bolus Slow release bolus

A - Human Necessities

61

K

167/170

A61K 31/635 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 31/65 (2006.01) A61K 47/00 (2006.01)

Patent

CA 1085727

SLOW RELEASE BOLUS Abstract of the Disclosure A composition for slowly releasing a veterinary medicament in a ruminant animal is described. The composition comprises a water-insoluble and water resistant binder, a therapeutically active substance ant a critical water-insoluble controlled release agent. The process of the invention includes the steps of adding a solution of a water-insoluble binder dissolved in an organic solvent to a mixture of a therapeutically active substance and a water-insoluble dense filler, stirring the mixture until free flowing granules are formed, drying the granules, blending the dried granules with a lubricant and a water insoluble controlled release agent and compressing the mixture into convenient veterinary dosage forms. When the veterinary composition is orally administered to a ruminant animal it remains in the animal's body for a desired period of time and the therapeutically active substance contained therein is released in a predictable and controllable pattern.

274351

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