C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/279, 260/306
C07D 403/06 (2006.01) C07D 209/42 (2006.01)
Patent
CA 1145747
ABSTRACT OF THE DISCLOSURE Novel N-amino alkyl indole compounds are disclosed. Thene compounds correspond to the Formula I Image I in said Formula R1 indicates the hydrogen atom, an alkyl group with 1 to 4 carbon atoms, which nay be substituted by a phenyl group, or the acetyl group; R2 indicates the hydroxy carbonyl grcup, an alkoxy carbonyl group with 1 to 4 alkyl carbon atoms, the cyano group, the amino carbonyl group, a mono-alkyl amino carbonyl group with 1 to 4 alkyl carbon atoms, or a di-alkyl amino carbonyl group with 1 to 4 alkyl carbon atoms, with the proviso that, when R2 is the hydroxy carbonyl group, then R1 is other than the hydrogen atom; A indicates an alkylene group with 2 to 5 carbon atoms; R3 and R4 are the same or different substi- tuents and indicate the hydrogen atom, an alkyl group with 1 to 4 carbon atoms, or R3 and R4 are an alkylene group forming, to- gether with the nitrogen atom to which they are attached, a heterocyclic ring with 5 to 7 ring members; and R5 and R6 are the same or different substituents and indicate hydrogen and halogen atoms, alkyl groups with 1 to 3 carbon atoms, alkoxy groups with 1 to 3 carbon atoms, of one of said substituents R5 and R6 being the nitro group or the tri- fluoro methyl group while the other one is the hydrogen atom. The acid addition salts of said compounds are also disclosed. The above mentioned novel N-amino alkyl indole compounds have a favorable effect upon the motility of the gastro-intestinal tract. the compounds are obtained, for instance, by reacting the alkali metal salts of a corresponding indole compound which is unsub- stituted at its nitrogen atom, with a halogen? alkyl amine.
357343
Heinemann Henning
Ohlendorf Heinrich-Wilhelm
Wolf Klaus-Ulrich
Marks & Clerk
Solvay Pharmaceuticals Gmbh
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