Cephalosporins

Details Cephalosporins Cephalosporins

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/24 (2006.01) A61K 31/545 (2006.01)

Patent

CA 1120466

S-1-17334C/77 ABSTRACT OF THE DISCLOSURE A compound of the formula (I): Image (I) wherein A is a moncyclic or polycyclic heteroaromatic ring con- taining at least one nitrogen atom as a hetero atom, which may be unsubstituted or substituted with one or more substituents; R is a phenyl group which can be unsubstituted or sub- stituted or a thienyl group; T is (1) a -CH2-S-HEt group, where Het is a tetrazolo- pyridazine ring, a triazolopyridazine ring, or a triazolopyridine ring, (2) a Image group where R1 and R2, which may be the same or different, each is a hydrogen atom or a (C1 - C4)- alkyl group, (3) A -CH2N3 group or (4) a -CH2S-D group in which D is a group selected from the group consisiting of Image , Image , Image and Image where m and n each is 0 to 3; with the proviso that (a) when T if the -CH2S-D group wherein D is as defined above, the HO-A-moiety is a Image group Abstract of the Disclosure continued: wherein B represents the non-metallic atoms necessary to complete a pyridine ring, a pyrimidine ring or a pyrazole ring, each of which may be un- substituted or substituted, and (b) when T is the -CH2N3 group, then R is a substituted phenyl group and the non-toxic, pharmaceutically acceptable salts thereof, processes for preparing the same, and anti-microbial compositions containing the same.

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