Process for the production of nocardicin a

Details Process for the production of nocardicin a Process for the production of nocardicin a

C - Chemistry, Metallurgy

12

P

195/89

C12P 19/00 (2006.01) C07D 205/085 (2006.01) C12P 17/10 (2006.01)

Patent

CA 1067435

ABSTRACT OF THE DISCLOSURE An improved process for preparing Nocardicin A by cul- turing a Nocardicin A-producing microorganism in a fermentation medium comprises, adding to the fermentation medium, at least one additive selected from shikimic acid, a carboxylic acid of the formula: Image (I) wherein A is alkylene group having hydroxy, amino, acylamino or oxo group, and n is an integer of 0-4; glycine, alanine, serine, homoserine, ?-aminobutyric acid and ?,.beta.-diaminopropionic acid, and derivatives of the carboxy group of these compounds, Nocardicin A is a known antibiotic.

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