N-alkynyl-n'-¬.omega.-¬optionally substituted (thiazolyl)...

Details N-alkynyl-n'-¬.omega.-¬optionally substituted (thiazolyl)... N-alkynyl-n'-¬.omega.-¬optionally substituted (thiazolyl)...

C - Chemistry, Metallurgy

07

D

260/310.5

C07D 277/20 (2006.01) C07D 277/28 (2006.01) C07D 277/38 (2006.01)

Patent

CA 1133909

SY-1602 Abstract of the Disclosure Compounds of the formula Image I wherein R1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R2 and R3 each are independently hydrogen, (lower)- alkyl, guanidino or -(CH2)pNR4R5; R4 and R5 each are independently hydrogen, (lower)alkyl or phenyl; n is 2 or 3; p is 1, 2 or 3; X is NR6 or CHR6; R6 is cyano, nitro, SO2Ar or SO2(lower)alkyl; and Ar is phenyl or phenyl containing 1 or 2 substituents selected from halogen and (lower)alkyl; and nontoxic, pharmaceutically acceptable salts thereof, are potent anti-ulcer agents. -1-

339769

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