Process for preparing cefazolin

Details Process for preparing cefazolin Process for preparing cefazolin

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/06 (2006.01) C07D 501/04 (2006.01) C07D 501/36 (2006.01) C07D 501/56 (2006.01) C07D 501/60 (2006.01) A61K 31/545 (2006.01)

Patent

CA 1052769

ABSTRACT OF THE DISCLOSURE The present invention relates to an improvement in the process for preparing 7-(1H-tetrazol-1-yl)acetamido- 3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4- carboxylic acid (cefazolin) by reacting a solvate of N,N- dimethylformamide and the hydrochloride salt of 7-amino-3- (2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-car- boxylic acid with 1H-tetrazole-1-acetyl chloride in the presence of N,N-dimethylacetamide as solvent. Cefazolin is a useful antibiotic.

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