C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/267.4, 260/2
C07D 243/08 (2006.01) C07C 243/38 (2006.01) C07D 295/22 (2006.01) C07D 295/28 (2006.01) C07D 295/32 (2006.01)
Patent
CA 1082181
ABSTRACT OF THE DISCLOSURE A compound of the formula (I), and pharmaceutically acceptable salts thereof: Image (I) wherein: R1 is a C1-6 alkoxy group; R2 and R3 are the same or different and are hydrogen, halogen, CF3, hydroxy, C1-6 alkoxy, C2-7 acyl, amino, amino substituted by one or two C1-6 alkyl groups, C2-10 acyl amino, aminosulphone, aminosulphone substituted by one or two C1-6 alkyl groups, C1-6 alkylsulphone or nitro groups; and A is a C2-4 alkylene group; R5 is hydrogen or a C1-6 alkyl group; R6 is hydrogen, a C1-6 alkyl group, or an aryl- C1-6 alkyl group in which the alkyl moiety is optionally substituted by a C1-6 alkyl or aryl group; R7 is a C1-6 alkyl group, or an aryl-C1-C6 alkyl group in which the alkyl moiety is optionally substituted by a C1-6 alkyl or aryl group; or R5 and R6 may be joined so that they form, with the -N-A-N- group to which they are attached, a 6, 7 or 8 membered heterocyclic ring; or A and R6 may be joined so that they form, with the nitrogen atom to which they are attached, a group -(CH2)m-R8-, wherein m is 0, 1 or 2 and R8 is a 5, 6 or 7 membered heterocyclic ring to a nitrogen atom of which is attached the R7 group; or R6 and R7 may be joined so that they form, with the nitrogen atom to which they are attached, a 5 or 6 membered heterocyclic ring. These compounds maybe used for treatment of disorders of the gastro-intestinal function. They may also be of use as anti-emetics. Some of the compounds may also be used as neuroleptics.
278662
Beecham Group Limited
Borden Ladner Gervais Llp
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