Bestatin, an enzyme inhibitor from streptomyces

Details Bestatin, an enzyme inhibitor from streptomyces Bestatin, an enzyme inhibitor from streptomyces

C - Chemistry, Metallurgy

12

P

195/122.5, 260/4

C12P 1/00 (2006.01) C12P 13/04 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1051801

ABSTRACT OF THE DISCLOSURE The invention relates to bestatin inhibiting aminopeptidase B, leucine aminopeptidase and bleomycin hydrolase, enhancing the antitumor effect of bleomycin and having the following structure and a process for the production thereof: Image which comprises cultivating Streptomyces olivoreticuli having the identifying characteristics of A.T.C.C. 31159 in a nutrient medium under aerobic condition until substantial activity to inhibit aminopeptidase B is imparted to said cultured medium. Bestatin may be recovered from said cultured medium by an extraction or adsorption method.

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