Substituted thienyl-acetic acid esters

Details Substituted thienyl-acetic acid esters Substituted thienyl-acetic acid esters

C - Chemistry, Metallurgy

07

D

260/279.25, 260/

C07D 333/24 (2006.01) C07D 333/28 (2006.01) C07D 333/32 (2006.01) C07D 333/34 (2006.01) C07D 333/44 (2006.01)

Patent

CA 1060894

A B S T R A C T Substituted thienyl-acetic acid esters of the formula: Image in which R1 and R2 each, independently is H, CH3, C2H5, C3H7, OCH3, SCH3, Cl Br or NO2, R3 is phenyl or cyclohexyl and R4 is H, or R3 and R4 together are cyclohexylidene, n is 2 or 3, and A is monoalkylamino or dialkylamino, the or each alkyl radical having 1 to 4 carbon atoms, or amino derived from a cycloalkylamine of 5 to 7 chain members which may contain an additional hetero-atom, provided that each of R1 and R2 is not H if R3 is phenyl or cyclohexyl and R4 is H, racemate, optical isomers, and their pharmaceutically acceptable acid addition salts and quaternary ammonium salts obtained with alkyl halides, have marked activity as peripheral vasodilators, platelet aggregation inhibitors, spasmolytic agents, coronary and cerebral vasodilators, and papaverine- like activity.

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