N-(4-pyrazolidinyl) benzamides

Details N-(4-pyrazolidinyl) benzamides N-(4-pyrazolidinyl) benzamides

C - Chemistry, Metallurgy

07

D

260/315.5

C07D 231/04 (2006.01)

Patent

CA 1105037

346-CIP-1 N-(4-PYRAZOLIDINYL)BENZAMIDES ABSTRACT OF THE DISCLOSURE N-(4-Pyrazolidinyl)benzamides having the formula Image are disclosed wherein R is lower alkyl, lower cycloalkyl or phenyllower-alkyl; R1 is lower alkyl, lower cycloalkyl, or phenyllower-alkyl; R2 is hydrogen, lower alkyl or phenyl; R3 is hydroxy, cyano, nitro, amino, fluoro, chloro, bromo, trifluoromethyl, lower alkyl, lower alkoxy, sulfamoyl or acetamido, R3 can be the same radical or different radicals; n is an integer from zero to three inclusive, and pharmaceutically acceptable acid addition salts thereof. The compounds have anti-emetic and gastric emptying properties.

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