C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/279.4, 260/2
C07D 413/04 (2006.01) A61K 31/44 (2006.01) C07D 417/04 (2006.01)
Patent
CA 1105463
- 1 - Abstract of the disclosure Compounds of formula I, Image I wherein R1 is hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl or alkinyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms,cycloalkyl- alkyl of 4 to 8 carbon atoms, phenylalkyl of 7 to 9 carbon atoms or phenylalkenyl of 9 to 12 carbon atoms, the phenyl ring being unsub- stituted or mono-, di- or trisubstituted in- dependently by halogen, hydroxy or alkyl or alkoxy of 1 to 4 carbon atoms, R2 and R5, independently, are hydrogen or alkyl of 1 to 6 carbon atoms, R3 and R4, independently, are alkyl of 1 to 6 car- bon atoms, alkenyl or alkinyl of 3 to 6 carbon - 2 - atoms, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 4 to 8 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxyalkoxy of 2 to 6 carbon atoms, alkoxyalkoxy of 3 to 6 carbon atoms, hydroxyalkoxyalkoxy of 4 to 8 carbon atoms, alkenyloxy or alkinyloxy of 3 to 6 car- bon atoms, cycloalkyloxy of 3 to 7 carbon atoms or cycloalkyalkoxy of 4 to 8 carbon atoms, R6 is hydrogen, halogen, alkyl or alkoxy or alkyl- thio or alkylsulfonyl, each of 1 to 4 carbon atoms, trifluoromethyl, nitro or hydroxy, and X is oxygen or sulphur are useful for treating coronary insufficiency and hyper- tension.
305727
Kirby Eades Gale Baker
Sandoz Ltd.
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