C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/249.2
C07D 498/04 (2006.01) C07D 211/98 (2006.01) C07D 251/66 (2006.01)
Patent
CA 1104134
EV 4019/79 ABSTRACT The present invention provides compounds of the general formula Image I , wherein R1 represents a hydrogen atom and R2 represents a group of the formula -?-R , -COOR5 or -CH(R6)COOR7 or R1 and R2 have the same significance and represent a hydrogen atom or a group of the formula -CH(R6)COOR7, R3 represents a diallylamino or 1,2,5,6-tetrahydropyridin-1-yl group, R4 represents an alkyl, haloalkyl, alkoxy- alkyl, aryloxyalkyl, aralkyloxyalkyl, aralkyl, alkoxycarbonylalkyl or aryl group, a group of the formula -C(R8)=C(R9)(R10), an alkoxycarbonylalkylcarboxyl group or a 4- -membered to 7-membered heterocyclic group which is optionally bound via a methylene group, R5 represents an alkyl, alkoxyalkyl, aralkyl, aryl or allyl group, R6 represents a hydrogen atom or an alkyl group, R7 (a) represents an alkyl group, and R8, R9 and R10 each represent hydrogen, an alkyl, aryl or aralkyl group or a 4-membered to 7-membered heterocyclic group, and their salts. These compounds and salts possess long- -lasting valuable vasodilating and/or blood pressure- -lowering properties and are suitable for the treatment of vascular-conditioned hypertension or as vasodilators in the case of peripheral blood supply disorders. The invention also provides a process for the manufacture of these com- pounds and salts. (b)
331391
Muller Jean-Claude
Ramuz Henri
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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