Process for the manufacture of new...

C - Chemistry – Metallurgy – 07 – C

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260/557, 260/597

C07C 45/71 (2006.01) A61K 31/00 (2006.01) C07C 45/00 (2006.01)

Patent

CA 1069923

Abstract of the Disclosure The invention concerns new compounds of the general formula I Image wherein each of Ar1, Ar2 and Ar3 is unsubstituted phenyl or phenyl substituted by one or more than one member of lower alkyl, lower alkoxy, halogeno, trifluoromethyl. nitro, amino, mono-lower alkylamino or di-lower alkylamino, lower alkanoyl- amino, cyano, carboxy, carbo-lower alkoxy, carbamoyl, amino- methyl, mono-lower alkylaminomethyl or di-lower alkylamino- methyl, Ph is unsubstituted phenylene or phenylene substituted by one member listed for Ar1, n is an integer from 0 to 4, each of m and p is an integer from 1 to 4, r is the integer 1 or 2 and R1 is hydrogen or hydroxy, or salts thereof. The compounds exhibit hypotensive and bradycardic activity. They are prepared by reducing compounds of the general formula III Image wherein one or both of X and Y is oxygen and the other is H2 and Z is free or protected NH. - 2 -

232735

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