Preparation of .beta.-lactam antibiotics

Details Preparation of .beta.-lactam antibiotics Preparation of .beta.-lactam antibiotics

C - Chemistry, Metallurgy

07

D

260/104.5, 260/1

C07D 499/16 (2006.01) C07D 499/00 (2006.01) C07D 501/04 (2006.01)

Patent

CA 1059118

ABSTRACT OF THE DISCLOSURE The present invention provides a process for the preparation of a sodium or potassium salt of a .beta.-lactam antibiotic which contains a .alpha.-amino group in the acylamino side chain which process comprises (a) the formation of a slurry of the zwitterionic form of the antibiotic in an organic solvent system which contains at least one lower alkanol; (b) bringing about the dissolution of the antibiotic by the addition of a sodium or potassium hydrozide or lower alkoxide; (c) precipitating the resulting salt from solution by the addition of an organic solvent and (d) isolating the precipitate. The process of this invention is particularly suitable for the preparation of the sodium or potassium salts of amoxycillin. Amoxycillin salts prepared by the process of this invention can be of higher purity than those produced by conventional procedures.

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