C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/305.05, 260/
C07D 231/56 (2006.01) A61K 31/415 (2006.01)
Patent
CA 1040640
ABSTRACT OF THE DISCLOSURE New compounds of the general formula (I) Image (I) and salts thereof were prepared by reacting a compound of the general formula (II) Image (II) with a compound of the general formula (III) or (IV) Image (III) Image (IV) and optionally saturating the -C=N- bond. In the above formulae R1 and R2 are always the same and represent a C1-4 alkyl group, R3 stands for hydrogen, R4 and R5 each represent an unsubstituted or substituted phenyl, cyclohexyl or a straight-chained C1-16 alkyl or alkyl- idene group, the latter two groups being optionally substituted by a cyclo- hexyl, an unsubstituted or substituted phenyl, an unsubstituted or nitro- substituted furyl or unsubstituted naphthyl group, wherein said substituted phenyl groups may contain up to three C1-3 alkoxy, hydroxy, benzyloxy, nitro, amino, di-C1-3 alkylamino, methylenedioxy, C1-3 alkylmercapto, C1-3 alkyl- sulfonyl or halogen substituents, and one of R4 and R5 may represent a hydro- gen atom, or R4 and R5 may form together with the adjacent carbon atom a C6-12 cycloalkyl, C6-12 cycloalkylidene, piperidyl, C1-3 alkyl substituted piperidyl or phenyl-C1-3 alkyl substituted piperidyl group, or R4 and R5 may form a naphthylidene or an unsubstituted or nitro-substituted furfurylidene group, and R6 and R7 may stand for hydrogen, or R6 and R7 may form together a valence bond, and the R8 groups may each represent hydrogen, C1-3 alkyl or C2-4 alkanoyl, or the R8 groups may form together a C1-3 alkylene or C2-4 alkanoylene group. The compounds of the general formula (I) possess primarily gastric acid secretion inhibiting and central nervous activities, furthermore they exert favourable action on the development of certain microorganisms which can be utilized in therapy.
207093
Kiszelly Eniko
Kosoczky Ibolya
Magdanyi Laszlo
Petocz Lujza
Varga Attila
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