Triazine derivatives

Details Triazine derivatives Triazine derivatives

C - Chemistry, Metallurgy

07

D

260/249.9

C07D 251/46 (2006.01) C07D 251/38 (2006.01) C07D 403/00 (2006.01)

Patent

CA 1108138

ABSTRACT TRIAZINE DERIVATIVES The invention concerns new analgesic 6- acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives of the formula:- Image I in which R1 is an optional]y substituted phenyl, phenyl- (1-4C)alkyl , naphthyl, monocyclic or bicyclic heteroaromatic or (monocyclic or bicyclic hetero- aromatic)- (4C)alkyl radical, R2 is a (3-8C)cycloalkyl, [(3-8C)cycloalkyl]-(1-4C)alkyl or (3-6C)alkenyl radical, or an optionally substituted phenyl or phenyl- (1-4C)- alkyl radical, and R3 is a (1-4C)alkyl radical, preferably a methyl radical; together with pharmaceut- ically acceptable salts thereof. Also provided are processes for the manufacture of, and pharmaceutical compositions of, derivativesof formula I and salts thereof. Some of the derivatives of formula I possess anti-inflammatory properties and/or are inhibitors of the enzyme prostaglandin synthetase in addition to possessing analgesic properties. A typical compound of the invention is 3- (thien-2-yl)-6-[(N-acetyl)isobutylamino]tetrahydro- 1,3,5-triazine-2,4 dione.

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