Synthesis of a-ring aromatic steroids

Details Synthesis of a-ring aromatic steroids Synthesis of a-ring aromatic steroids

C - Chemistry, Metallurgy

07

C

260/355, 260/579

C07C 45/00 (2006.01) C07C 49/417 (2006.01) C07C 49/76 (2006.01) C07D 325/00 (2006.01) C07J 1/00 (2006.01)

Patent

CA 1040209

Abstract A process for the preparation of a compound of the formula Image II wherein R is lower n-alkyl, R' is tertiary lower alkyl or a group of the formula Image wherein R2 is hydrogen or lower n-alkyl, R3 and R4 each taken independently is lower n-alkyl, and R3 and R4 taken together is lower alkylene of from 3 to 6 carbon atoms, and R" is lower n-alkyl, tertiary lower alkyl, benzyl, diphenylmethyl or trityl, which comprises contacting a compound of the formula Image I wherein R and R' are as above, with a compound of the formula Image wherein R" is as above and M is magnesium halide, lithium or copper, in an inert organic solvent and, where M is magnesium halide or lithium, in the presence of cuprous ion, and hydrolyzing the product in an aqueous medium.

182580

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