Thipyrano benzopyrans, intermediates for their preparation...

Details Thipyrano benzopyrans, intermediates for their preparation... Thipyrano benzopyrans, intermediates for their preparation...

C - Chemistry, Metallurgy

07

D

260/328

C07D 495/04 (2006.01)

Patent

CA 1051005

ABSTRACT OF THE DISCLOSURE Novel thiopyranolbenzopyrans represented by the formula Image wherein R1 is loweralkyl; R2 is alkyl or cycloalkylloweralkyl and R3 is hydrogen, loweralkyl, loweralkanoyl, carbamyl, N-loweralkyl- carbamly, N,N-diloweralkylcarbamyl, phosphonyl, or dialkylamino- alkyl of the structure Image or acid addition salt thereof, or dialkylaminoalkanoyl of the structure Image or acid addi- tion salt thereof, wherein x is 1 through 6 and R4 and R5 are lower- alkyl; the loweralkyl groups containing from 1 through 6 carbon at- oms, the alkyl groups containing from 1 through 20 carbon atoms and the cycloalkyl groups containing from 3 through 8 ring carbon atoms. Novel intermediates for the synthesis of these compounds are also disclosed as well as methods for making the compounds. The compounds exhibit CNS activity and are useful as anti-anziety agents. They can also be used in treating anziety with or without associated psychoneurotic depressive symptoms.

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