Diuretic formulations

A - Human Necessities – 61 – K

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167/193, 167/224

A61K 31/57 (2006.01) A61K 31/495 (2006.01) A61K 31/585 (2006.01) C07D 241/26 (2006.01) C07D 333/22 (2006.01)

Patent

CA 1075155

ABSTRACT OF THE DISCLOSURE The potassium conserving diuretics, N-amidino- 3,5-diamino-6-chloropyrazinecarboxamide and its hydro- chloride, 2-oxygenated-6,7-methylene-2?-spirozanes; 17-a- pregnase-21-carboxylic acids and spironolactone are orally co-administered with 4-substituted carbonyl-2,3-dichloro- phenoxyacetic acid diuretics wherein the substituents are furyl, thienyl, or loweralkylthienyl as mixtures or, in the instance of N-amidino-3,5-diamino-6-chloropyrazinamide, as salts to avoid hypokalemia in patients.

244829

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