C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/239.3
C07D 487/04 (2006.01)
Patent
CA 1043784
ABSTRACT OF THE INVENTION 1-piperazino-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzo- diazepines of the formula II: Image II wherein R is hydrogen, alkyl of 1 to 3 carbon atoms, inclusinve, or .beta.-hydroxyethyl; wherein R1 is hydrogen or alkyl defined as above; and wherein R2, R3, R4 and R5 are hydrogen, alkyl as defined above, fluoro, chloro, bromo, nitro or trifluoromethyl, are obtained by reacting a compound of the formula I: Image I wherein R1, R2, R3, R4 and R5 are defined as above, with a piperazine of the formula: Image -1- wherein R is defined as above. The compounds of the formula II and their pharmacologically acceptable acid addition salts thereof, have tranquilizing, sedative and anti-depressant effects, and are useful for suppression of anxiety and depression in mammals and birds. -1a-
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