Process for the production of vaccine

Details Process for the production of vaccine Process for the production of vaccine

A - Human Necessities

61

K

167/135

A61K 39/00 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1156553

ABSTRACT OF THE DISCLOSURE The present invention relates to a process for the production of vaccine, characterized by covalent attachment of a biologically toxic substance to saccharide both to form a biologically toxic substance-saccharide conjugate and to detoxificate said substance, and by collection of the formed conjugate. According to the invention, various vaccine products having a high productivity of immunoglobulin G and M antibodies, but without productivity of immunoglobulin E antibody, are easily obtainable. In addition, the vaccine products, upon administration to animals, do not effect any allergy and/or anaphylactic-shock due to the lack of the immunogiobulin E antibody production.

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