Process for producing an insulin precursor

Details Process for producing an insulin precursor Process for producing an insulin precursor

C - Chemistry, Metallurgy

07

K

530/7.1, 530/7.4

C07K 1/06 (2006.01) C07K 1/12 (2006.01) C07K 14/62 (2006.01)

Patent

CA 1154435

X-5499A Abstract of the Disclosure A process for preparing a proinsulin-like disulfide insulin precursor is described by reacting its corresponding linear chain S-sulfonate insulin precursor with a mercaptan in an amount which provides from about 1 to about 5 -SH moieties per -SSO3 moiety in an aqueous medium at a pH of from about 7 to about 11.5 and at an S-sulfonate concentration of up to about 10 mg. per ml. of aqueous medium.

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