C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
150/15, 150/2, 1
C12Q 1/00 (2006.01) C12Q 1/28 (2006.01) G01N 33/52 (2006.01)
Patent
CA 1166132
ABSTRACT OF THE DISCLOSURE Analytical element method of making the analy- tical element and process for determining an analyte in a body fluid sample are disclosed. More parti- cularly, the method of preparing the element com- prises the steps of: (a) impregnating a carrier with a first solution, having a pH not greater than about 2.5, which comprises a polymeric mordant and a tetraalkylbenzidene dihydrochloride, in a molar concentration greater than that of the polymeric mordant in an aqueous solvent and drying the carrier; (b) impregnating the carrier of (a) with a solution, having a pH of at least about 7.0, which comprises an analyte-responsive component in an aqueous solvent and drying the carrier. Optionally, there can be added the step of impregnating the carrier of (b) with a solution of a semi-permeable polymer in an organic solvent and drying the carrier.
407318
Miles Laboratories Inc.
Osler Hoskin & Harcourt Llp
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