Substituted pyranone inhibitors of cholesterol synthesis

Details Substituted pyranone inhibitors of cholesterol synthesis Substituted pyranone inhibitors of cholesterol synthesis

Category

C - Chemistry, Metallurgy

Subcategory

07

Subsubcategory

D

CPC

260/359.4

IPC codes

C07D 309/28 (2006.01) C07D 309/30 (2006.01)

Type

Patent

Patent number

CA 1137989

Description

16364IA TITLE OF THE INVENTION SUBSTITUTED PYRANONE INHIBITORS OF CHOLESTEROL SYNTHESIS ABSTRACT OF THE DISCLOSURE 6-Phenyl-, phenalkyl- and phenylethenyl- 4-hydroxytetrahydropyran-2-ones in the 4- R trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by the enzyme hydroxymethyl- glutaryl coenzyme A reductase.

Application Number

358416

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