Substituted benzamides and derivatives thereof

Details Substituted benzamides and derivatives thereof Substituted benzamides and derivatives thereof

C - Chemistry, Metallurgy

07

D

260/325, 260/267

C07D 295/14 (2006.01) C07D 207/08 (2006.01) C07D 207/09 (2006.01) C07D 295/13 (2006.01)

Patent

CA 1064930

ABSTRACT OF THE DISCLOSURE Novel benzamides are provided which correspond to the formula: Image in which A represents a hydrogen atom, a C1-5 alkyl group, or a C2-5 alkenyl group; X represents a hydrogen atom, a C1-5 alkoxy group, a C1-5 alkyl group, a C2-5 alkenyloxy group, or a C2-5 alkenyl group; Y represents a hydrogen atom, a halogen atom, a nitro group, a C1-5 alkyl group, a C1-5 alkoxy group, an amino group, a substituted amino group such as for example alkyl- amino, acylamino, benzylamino or alkoxycarbonylamino; Z repre- sents a hydrogen atom, a halogen atom, a C1-5 alkoxy group, a C1-5 alkylsulphonyl group, a SO2NR1R2 group in which R1 and R2, which may be the same or different, are hydrogen or a lower C1-5 alkyl group, or form, together with the nitrogen atom to which they are attached, a heterocycle optionally containing another hetero atom; W represents an alkylene group with 1 to 4 carbon atoms which may form a straight or branched chain; B represents a group NR1R2 in which R1 is a C1-5 alkyl group, R2 is a C1-5 alkanol group, and the group R1 may be joined to the alkyl chain of the group R2 via a nitrogen atom, or a racemic, dextrorotary or levorotary heterocyclic radical of the follow- ing formula: Image in which R is a C1-5 alkyl group containing a reactive function such as alcohol, thiol, ketone, thioketone, ether oxide, thio- ether, etc., and m is an integer equal to 1, 2 or 3. The novel benzamides possess antiemetic properties.

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