14,15-dihydro-eburnamenine compounds

Details 14,15-dihydro-eburnamenine compounds 14,15-dihydro-eburnamenine compounds

C - Chemistry, Metallurgy

07

D

260/272

C07D 455/02 (2006.01) C07D 461/00 (2006.01)

Patent

CA 1066706

ABSTRACT OF THE DISCLOSURE New compounds of the general formula (I) (I) Image wherein R1 stands for alkyl and R2 stands for carboxy, a functional carboxy derivative or a group convertable into carboxy group or a functional derivative thereof, have been prepared by reducing a compound of the general formula (II) . Image (II) wherein R1 and R2 each have the same meanings as defined above and X- represents an anion derived from an acid, and optionally subjecting the obtained compound to hydro- lysis, If desired, the racemic compounds of the general formula (I) can be resolved to yield the corresponding optioally active isomers. The free bases of the general formula (I) can be converted into their pharmaceutically acceptable salts, or the salts can be treated with an al- kaline agent to yield the free bases, The compound of the general formula (I) can be used in the therapy primarily as vasodilatating agents.

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