Tripeptides and method

Details Tripeptides and method Tripeptides and method

C - Chemistry, Metallurgy

07

K

530/5.08

C07K 5/09 (2006.01)

Patent

CA 1141375

ORTH 326 ABSTRACT NEW TRIPEPTIDES AND METHODS There are disclosed new biological active polypeptides: A-X-B wherein A is deamino-LYS or LYS; X is a suitable neutral aliphatic amino acid residue; e.g., one selected from the group consisting of SER, ALA, 2-Me-ALA, GLY, LEU, THR, D-SER, D-ALA, D-THR, allo-THR, D-LEU, and SAR; B is GLN-R', decarboxy-GLN, or Image ; and R' is a substituent which does not substantially affect the biological activity of the tripeptide. These polypeptides have the capability of in- ducing the differentiation of T-lymphocytes as measured by the acquisition of the thymic differentiation antigen Th-l, as well as B-lymphocytes as measured by the acquisi- tion of the differentiation antigen Bu-l. The polypeptides are thus useful in thymic function and immunity areas such as in treatment for congenital absence of thymus. Also provided are therapeutic compositions and methods for use of the polypeptides.

347571

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