Process for preparing cephalosporines

Details Process for preparing cephalosporines Process for preparing cephalosporines

C - Chemistry, Metallurgy

07

D

260/104

C07D 501/20 (2006.01) C07D 501/06 (2006.01)

Patent

CA 1077029

ABSTRACT OF THE DISCLOSURE: A process for preparing cephalosporines in which a ce- phalosporanic derivative is treated with a polar solvent, then with an organic base to give a mixture which is cooled at a temperature lower than -25°C. A cyclic derivative of boron is added to the mixture and the temperature is increased to about 0°C. An inter- mediate compound is formed which by treatment first with an acylat- ing agent and then with a mixture of water and alcohol provides a solution containing cephalosporines.

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