Substitutes n-methylene derivatives of thienamycin

Details Substitutes n-methylene derivatives of thienamycin Substitutes n-methylene derivatives of thienamycin

C - Chemistry, Metallurgy

07

D

260/299, 260/277

C07D 487/04 (2006.01) C07D 205/08 (2006.01) C07D 477/20 (2006.01) C07D 498/04 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1083577

ABSTRACT OF THE DISCLOSURE Disclosed are substituted N-methylene derivatives of thienamycin which may be represented by the following structural formula: Image wherein X and Y are selected from the group consisting of hydrogen, R, OR, SR, and NR1R2 wherein, inter alia, R is substituted or unsubstituted: alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, and heterocyclylalkyl; R1 and R2 are hydrogen or R. Such compounds and their pharmaceutically acceptable salt, ether, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharma- ceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

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