Glycerides with anti-inflammatory properties

Details Glycerides with anti-inflammatory properties Glycerides with anti-inflammatory properties

C - Chemistry, Metallurgy

07

C

260/472, 260/207

C07C 69/52 (2006.01) C07C 69/76 (2006.01) C07D 209/28 (2006.01) C11C 3/04 (2006.01)

Patent

CA 1067488

ABSTRACT OF THE DISCLOSURE Triglycerides carrying the anti-inflammatory drug moiety in the 2-position and hydrocarbon acyl moieties in the 1- and 3-positions exhibit excellent anti-inflammatory properties without causing the side effects often associated with the anti- inflammatory drug itself. More specifically, there is disclosed the process of preparing a compound of the formula: Image wherein R is an acyl derivative of the formula CH3-X-CO- wherein X represents a saturated or unsaturated, divalent carbon chain of 0 - 18 carbon atoms and wherein R' is the acyl moiety of an organic, pharmaceutically acceptable acid having anti-inflammatory properties, characterized in that dihydroxyacetone is first esterified with two molar equivalents of ROH wherein R is the above acyl group or an active derivative thereof, reducing the so obtained di-ester ketone to the corresponding alcohol, and reacting the so obtained dialkanoyl- glycerol with the acid chloride of R'.

236743

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