Histamine h-2 receptor antagonists

Details Histamine h-2 receptor antagonists Histamine h-2 receptor antagonists

C - Chemistry, Metallurgy

07

D

260/305

C07D 233/54 (2006.01)

Patent

CA 1062263

ABSTRACT Pharmacologically active compounds which are histamine H-2 receptor antagonists are disclosed. The compounds may be represented by the following general formula: Image wherein R1 and R2, which may be the same or different, each represent a grouping of the structure; Image wherein Het is an imidazole optionally substituted by lower alkyl or halogen, Z is sulphur or a methylene group; m is 0, 1 or 2; n is 2 or 3 and the sum of m and n is 3,4, X and X2, which may be the same or different, are sulphur, CHN02 or NY wherein Y is hydrogen, hydroxy, lower alkyl, cyano, CONH2 or S02R3 is lower alkyl, substituted or unsubstituted aryl, trifluoromethyl or amino; W is N??, and when X1 and X2 are NH, W may also be sulphur; and q is an integer from 2 to 8.

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