C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/304, 260/311
C07D 413/12 (2006.01) C07C 43/12 (2006.01) C07C 45/61 (2006.01) C07C 45/64 (2006.01) C07C 45/70 (2006.01) C07D 261/08 (2006.01) C07F 9/653 (2006.01)
Patent
CA 1157476
ABSTRACT OF THE DISCLOSURE The prevent invention is directed to novel amino- propanol derivatives of 5-(2-hydroxystyryl)-isoxazole of the formula (I) Image (I) where n is 1 or 2, o is 1, 2 or 3, R1 and R2 are each hydrogen or straight-chain or branched alkyl of 1 to 5 carbon atoms, R3 is hydrogen, hydroxyl, halogen alkyl, alkoxy or alkylthio of 1 to 5 carbon atoms, (the last-mentioned three groups each being unsubstituted, or mono-, di or tri-substituted by halogen or mono-substituted by hydroxyl or alkoxy of 1 to 3 carbon atoms), alkenyl, alkynyl, alkynyloxy or cycloalkoxy, each of 2 to 6 carbon atoms in the alkyl and of 3 to 8 carbon atoms in the ring or amino which is unsubstituted or is mono- or di-substituted by alkyl of 1 to 5 carbon atoms, and if o is 2 or 3, the R3's may be identical or different, or R3 is methylenedioxy or alkylene of 3 or 4 carbon ? o , and R4 is alkyl of 1 to 4 carbon atoms, and their addition salts with acids. This invention is also concerned with the preparation of said novel compounds, their use in the treatment of hypertonia, coronary heart disease and cardiac arrhythmias.
362510
Franke Albrecht
Frickel Fritz-Frieder
Gries Josef
Lenke Dieter
Theobald Hans
Basf Aktiengesellschaft
Robic Robic & Associes/associates
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