Process for preparing 3,4-dihydro-2(1h)-quinazolinone...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/78 (2006.01) C07D 239/82 (2006.01)

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CA 1049521

A NOVEL PROCESS FOR PREPARING 3,4-DIHYDRO-2(1H)-QUINAZOLINONE DERIVATIVES ABSTRACT OF THE DISCLOSURE 3,4-Dihydro-2(1H)-quinazolinones and quniazolinethiones such as 1-cyclopropylmethyl-4-phenyl- 6-methoxy-3,4-dihydro-2(1H)-quinazolinone and its thione derivative, are prepared in high yield with high purity by heating the corresponding arylurea or thiourea such as N-cyclopropylmethyl-N-(p-methoxyphenyl) urea or its thiourea derivative, with the corresponding aldehyde such as benzaldehyde in the presence of hydrobromic acid in an inert solvent.

263980

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