Substituted aromatic esters of 16-substituted pge2

Details Substituted aromatic esters of 16-substituted pge2 Substituted aromatic esters of 16-substituted pge2

C - Chemistry, Metallurgy

07

C

260/235.03

C07C 405/00 (2006.01)

Patent

CA 1049510

ABSTRACT OF THE DISCLOSURE Substituted phenyl and naphthyl esters of PGE2 ana- logs, including the 16-alkyl, 16-fluoro, 16-phenoxy, and phenyl-substituted analogs, and their 15-epimers, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharma- cological and medical purposes as these PGE2 analogs, and are also useful as a means for obtaining highly purified 16,16-dimethyl-PGE2, 16-phenoxy-17,18,19,20-tetranor-PGE2, and 17-phenyl-18,19,20-trinor-PGE2. -1-

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