Thieno ¬2,3-d| pyrimidine antiallergic agents

Details Thieno ¬2,3-d| pyrimidine antiallergic agents Thieno ¬2,3-d| pyrimidine antiallergic agents

C - Chemistry, Metallurgy

07

D

260/242.5

C07D 495/04 (2006.01) C07D 333/38 (2006.01) C07D 333/68 (2006.01) C07D 498/04 (2006.01)

Patent

CA 1094063

THIENO [2,3-D]PYRIMIDINE ANTIALLERGIC AGENTS Abstract of the Disclosure 2-Aminothiophene-3-carboxamides are converted to oxamates or fumaramides by acylation of the amino group. Cyclization yeilds thieno[2,3-d]pyrimidines which may also be prepared from the corresponding oxazines. Compounds illustrative of those having inhibitory action on the immediate hypersensitivity reaction in mammals are N-[3-(amino- carbonyl)-4,5,6,7-tetrahydrobenzo[b]thein-2-yl]oxamic acid, ehtyl 5,6,7,8- tetrahydro-4-oxo-4H-benzothieno[2,3-d][1,3]oxazine-2-carboxylate, and ethyl 3,4-dihydro-6-ethyl-4-oxothieno[2,3-d]pyrimidine-2-carboxylate.

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