Synthesis of indolines

Details Synthesis of indolines Synthesis of indolines

C - Chemistry, Metallurgy

07

D

260/320

C07D 209/04 (2006.01)

Patent

CA 1161046

ABSTRACT OF THE INVENTION A process for the preparation of compounds of the structure Image wherein R is hydrogen, lower alkyl containing 1 to 5 carbon atoms, cycloalkyl containing 3 to 7 carbon atoms, phenyl or phenyl substituted with halogen, trifluoromethyl, or lower alkyl or lower alkoxy having 1 to 4 carbon atoms and R1 is hydrogen, lower alkyl having 1 to 4 carbon atoms, phenyl or phenyl lower alkyl wherein the lower alkyl has 1 to 4 carbon atoms, which comprises cyclizing a compound of the structure Image wherein R and R1 are as defined above, in the presence of a Lewis or Bronsted acid or mixtures thereof.

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