Preparation of 5-(arylcyanohydroxymethyl)-1-...

C - Chemistry – Metallurgy – 07 – D

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C07D 207/337 (2006.01)

Patent

CA 1157029

PREPARATION OF 5-(ARYLCYANOHYDROXY)METHYL-1-LOWERALKYL- PYRROLE-2-ACETIC ACID DERIVATIVES AND 5-AROYL-1-LOWERALKYL- PYRROLE-2-ACETIC ACID DERIVATIVES Abstract 5-(Arylcyanohydroxy)methyl-1-loweralkylpyrrole-2-acetic acid derivatives are prepared by the protic acid catalyzed reaction of aroylcyanides with 1-loweralkylpyrrole-2- acetic acid derivatives, which is then converted by treatment with alkali metal hydroxides or heat to form 5-aroyl-1-loweralkylpyrrole-2-acetic acid or derivatives thereof. In addition, 5-aroyl-1-loweralkylpyrrole-2- acetic acid derivatives are prepared by the reaction at above 100°C of an aroylcyanide with a 1-alkylpyrrole-2- acetic acid derivative.

415135

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