Method for removal of thiol-protecting groups

Details Method for removal of thiol-protecting groups Method for removal of thiol-protecting groups

C - Chemistry, Metallurgy

07

K

260/526, 530/1.0

C07K 1/12 (2006.01) C07K 1/06 (2006.01) C07K 5/06 (2006.01) C07K 5/083 (2006.01) C07K 5/103 (2006.01) C07K 14/655 (2006.01)

Patent

CA 1074300

ABSTRACT OF THE DISCLOSURE A novel method for removal of protective group(s) from an amino acid or peptide having thiol group(s) protected with p-methoxybenzyl, 1-adamantyl or t-butyl group by treating the protected amino acid or peptide with mercuric salt of acetic acid or halogenoacetic acid, the removal being effected selectively and very smoothly in a good yield under extremely mild condition without giving any undesirable influence upon other functional or protective group(s).

279924

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