Certain 6h-pyrimido (1,2-c) (1,3,5) benzothiadiazo compounds

C - Chemistry – Metallurgy – 07 – D

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260/238.5, 260/2

C07D 513/04 (2006.01) C07C 323/09 (2006.01) C07C 323/66 (2006.01) C07D 239/42 (2006.01)

Patent

CA 1051429

ABSTRACT This invention relates to compounds of the formula Image I wherein m is 1 or 2; when m is 1, R occupies either position-4 or -5 of the starting 2-aminopyrimidine, but when R is halogen, it occupies only position-5; when m is 2, the two R's occupy the 4- and 5-positions of the starting 2-aminopyrimidine, but only one of the two R-substituents can be halogen and it must occupy the 5-position; R is the same or different and is hydrogen, F, C1, Br, alkyl of from 1 to 4 carbons, benzyl, phenyl or mono-substituted phenyl wherein the substituent is F, Cl, Br, I, alkyl of from 1 to 4 carbons, alkoxy of from 1 to 4 carbons, or trifluoromethyl; R' is hydrogen, F, Cl, Br, CF3, alkyl of from 1 to 4 carbons, or dialkylamidosulfonyl wherein each alkyl radical has from 1 to 4 carbons; n is 0 or 1; R" is hydrogen or alkyl of from 1 to 4 carbons; Z is S or SO2, and pharmaceutically acceptable acid-addition salts thereof and a process for preparing them and to intermediates therefor. These compounds exhibit central nervous system stimulating properties and act as muscle relaxants.

203661

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