Stabilized antibiotic formulations

Details Stabilized antibiotic formulations Stabilized antibiotic formulations

A - Human Necessities

61

K

167/159, 167/185

A61K 47/02 (2006.01)

Patent

CA 1129344

ABSTRACT This invention relates to color-stabilized aqueous parenteral antibiotic compositions of a parenterally acceptable salt of an aminoglycoside antibacterial agent, having a pyranose ring which is unsaturated between the 4' and 5' positions and which contains an aminoalkyl substituent at the 5' position and to a process for their preparation. Such stable compositions have an initial pH of 5.0 - 7Ø The preferred pH range is 5.8 - 6.8 and the most preferred range is 6.2 - 6.5. The pH may be adjusted either by adding NaOh to the solution or, preferably, by including certain sulfite salts as antioxidants in such quantities that the desired pH is achieved.

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