C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/320
C07D 209/10 (2006.01) C07D 209/08 (2006.01)
Patent
CA 1065326
HEXAHYDRO-4-PHENYL-4-HYDROXY-INDOLINE Abstract of the Disclosure This invention provides new compounds of formula I, Image I wherein R1 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, fluorine, chlorine or hydroxy, and R2 is i) alkyl of 1 to 4 carbon atoms, ii) alkenyl or alkynyl of 3 to 7 carbon atoms, wherein the multiple bond is located in a position other than .alpha. to the nitrogen atom to which R2 is bound, iii) cycloalkyl of 5 to 7 carbon atoms, iv) alkyl of 1 to 4 carbon atoms mono- substituted by cycloalkyl of 3 to 7 carbon atoms, v) hydroxyalkyl of 2 to 4 carbon atoms, wherein the hydroxy moiety is attached to a carbon atom other than a carbon atom a to the nitrogen atomo to which R2 is bound, vi) a group -(CH2)p-CO-A, wherein p is a whole number from 1 to 3 and A is alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, or vii) a group Image wherein R3 and R4, independently, are hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, or halogen, and either X is a direct bond, vinylene or carbonyl and n is a whole number from 1 to 5 or X is -O-, -S-, -SO-, -SO2- or -NR5-, wherein R5 is hydrogen, phenyl, alkyl of 1 to 4 carbon atoms or alkanoyl of 2 to 4 carbon atoms, and n is a whole number from 2 to 5, useful as anti-depressants and anti-arrhythmics.
241104
Berthold Richard
Troxler Franz
LandOfFree
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